id author title date pages extension mime words sentences flesch summary cache txt cord-281937-yztlb0fn Sheahan, Timothy P The continued epidemic threat of SARS-CoV-2 and implications for the future of global public health 2020-06-04 .txt text/plain 2456 120 54 A new paradigm for human coronavirology was born with the emergence of severe acute respiratory syndrome CoV (SARS-CoV) in November 2002 in Guangdong Province, China. The epidemic strain of SARS-CoV, is believed to have emerged from a bat reservoir through a civet intermediate host in live animal markets and then spilled over into humans 2 . This notion of CoV emergence was further solidified with discovery of the novel highly pathogenic Middle East respiratory syndrome CoV (MERS-CoV) in 2012, which also likely emerged from an ancestral bat-CoV but through a camel intermediate host which continues to seed human MERS-CoV infections to this day 2,3 . Given the diversity and prevalence of CoV circulating among wild birds and mammals, it is not surprising that the potential for emerging CoV to cause severe disease outbreaks and epidemics is not limited to humans. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence ./cache/cord-281937-yztlb0fn.txt ./txt/cord-281937-yztlb0fn.txt