id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280671-0b1qcdwk	Calderone, Alba	Selective Estrogen Receptor Modulators in COVID-19: A Possible Therapeutic Option?	2020-07-15		.txt	text/plain	1555	82	37	In particular, susceptibility to SARS-CoV-2 infection is almost similar in both genders, but higher severity and mortality are observed in male patients (Wenham et al., 2020) . The previous severe acute respiratory syndromes caused by SARS-CoV and MERS-CoV were often associated with rapid viral replication, huge infiltration of inflammatory cells, and excessive production of proinflammatory cytokines (cytokine storm syndrome), leading to lung injury and respiratory distress syndrome . Moreover, pro-inflammatory cytokines, including IL-1b and IL-6, are directly induced by SARS-CoV-2 by interaction between viral components (probably nucleocapsid proteins) and toll like receptors of the host cells. Besides their potential effects on proinflammatory cytokine expression (mediated by ERs), some SERMs seem to play broader roles in inhibiting viral replication by ER-independent mechanisms. Anti-inflammatory effect of selective estrogen receptor modulators (SERMs) in microglial cells	./cache/cord-280671-0b1qcdwk.txt	./txt/cord-280671-0b1qcdwk.txt