id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280172-6o1gqe8v	Sanami, Samira	Design of a Multi-epitope Vaccine against SARS-CoV-2 using Immunoinformatics approach	2020-07-15		.txt	text/plain	5835	307	55	In this research, first, the CTL, HTL, and B-cell epitopes of the S protein were predicted using ProPred-1, ProPred, and ABCPred servers, respectively, and then were selected base on antigenicity, toxicity, allergenicity, and cross-reactivity with human proteomes. Next, the physicochemical properties of the construct were investigated, the 3D structure of the protein was predicted, and finally, its affinity to the MHC I and II molecules was investigated through docking, following that, was performed the molecular dynamics (MD) simulation of docking complexes. The antigenicity of the epitopes were calculated by VaxiJen v2.0 server (http://www.ddgpharmfac.net/vaxijen/VaxiJen/VaxiJen.html), which is based on the transformation of the protein sequences auto cross-covariance (ACC) into uniform vectors of main amino acid properties. selected N, M, and S proteins as the target antigen for the prediction of T and B-cell epitopes and designed a multi-epitope vaccine against SARS-CoV-2 [48] .	./cache/cord-280172-6o1gqe8v.txt	./txt/cord-280172-6o1gqe8v.txt