id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279766-s3ms5f56	Ye, Zhongde	A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis	2008-07-28		.txt	text/plain	3408	181	46	title: A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis All these data suggest that ORF-6 induces apoptosis via Caspase-3 mediated, ER stress and JNK-dependent pathways. We observed that ORF-6 was able to induce apoptosis when overexpressed in Vero E6 and COS-7 cells (Fig. 1A and B) . The death rates were comparable to the rates caused by the overexpression of Bax, a well-known pro-apoptotic member of the Bcl-family, and ORF-7a, a SARS protein that has been shown to induce apoptosis [19] . Our observation suggests that overexpression of ORF-6 induced apoptosis via a Caspase-3-dependent pathway. One of the possible mechanisms for SARS protein-induced cell death is via the JNK pathway. Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells	./cache/cord-279766-s3ms5f56.txt	./txt/cord-279766-s3ms5f56.txt