id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279519-4ad8ubrt	Poochi, Saravana Prabha	Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS‐CoV‐2 main protease and ACE2 protein	2020-07-06		.txt	text/plain	2363	146	50	title: Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS‐CoV‐2 main protease and ACE2 protein Angiotensin converting enzyme 2 (ACE2) and main protease (M(Pro)) are significant target proteins, mainly involved in the attachment of viral genome to host cells and aid in replication of severe acute respiratory syndrome‐coronaviruses or SARS‐CoV genome. In the present study, we identified 11 potent bioactive compounds from ethanolic leaf extract of Ipomoea obscura (L.) by using GC‐MS analysis. These potential bioactive compounds were considered for molecular docking studies against ACE2 and M(Pro) target proteins to determine the antiviral effects against SARS‐COV. In this investigation we performed in silico docking by applying Glide 5.5 (Dik-Lung, Daniel, & Chung, 2011; Glide, 2009 ), against respiratory therapeutic target ACE2 exhibited in human and M Pro in SARS-CoV-2. Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS-CoV-2 main protease and ACE2 protein	./cache/cord-279519-4ad8ubrt.txt	./txt/cord-279519-4ad8ubrt.txt