id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277705-6lgt2i7f	Luan, Junwen	A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2	2020-04-10		.txt	text/plain	1149	89	64	An RGD motif (403-405) was identified in SARS-CoV-2 S protein ( Figure 1A ). These results suggested that RGD/KGD integrin-binding motif is conserved in several coronaviruses including SARS-CoV-2 and SARS-CoV. To investigate whether RGD/KGD motif in S proteins from SARS-CoV-2 We identified a KGD motif in 353-355 of ACE2 (BAB40370.1), which is a key region for binding S protein ( Figure 1F ). Integrin associates with ACE2 through its KGD motif including K353, which is one of key AAs for S protein recognition. Integrin associates with S protein by its RGD/KGD motif, which would shield the space of RBM for contacting with ACE2. Because RGD recognized a broader spectrum of integrins than KGD, more integrins could block receptor binding of SARS-CoV-2 S than that of SARS-CoV S. In conclusion, we identified an RGD/KGD integrin-binding motif in S proteins from SARS-CoV-2 and SARS-CoV.	./cache/cord-277705-6lgt2i7f.txt	./txt/cord-277705-6lgt2i7f.txt