id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277585-evw3pu87	Malavolta, Marco	Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats	2020-04-08		.txt	text/plain	4183	211	36	Drugs targeting IL-6 have been included among the potential strategies to inhibit the deleterious consequences of the senescence-associated secretory phenotype (SASP), the secretome produced by senescent cells [31, 32] . The evidence that patients with cancer, hypertension or with smoking habits (conditions associated with a pathological role of cellular senescence) experienced worse outcomes from COVID-19 [71] , further supports the hypothesis that an accumulation of senescent cells may favor the development of severe events during SARS-CoV-2 infection. In the case of dengue virus infection, cellular senescence seems to exert an anti-viral function [64] but other viruses, such as IFV, have evolved mechanisms to increase replication in senescent cells [68] . Clarifying the role of cellular senescence in SARS-CoV infection may additionally provide a strong rationale for the use of senotherapeutics, such as SASP inhibitors, in the management of elderly patients affected by COVID-19.	./cache/cord-277585-evw3pu87.txt	./txt/cord-277585-evw3pu87.txt