id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277549-sg7tzhdm	Stanley, Kate E.	Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues	2020-05-08		.txt	text/plain	5364	249	47	Single cell RNA sequencing (scRNAseq) in human and non-human primate respiratory tissues have shown co-expression of ACE2 and TMPRSS2 in pneumocytes in the lungs and goblet secretory cells in the nose (6) , indicating that these cell types may serve as foci for infection and potentially explaining the range of respiratory symptoms associated with COVID-19. Cell-type specific expression patterns of genes that produce viral host entry proteins, and identification of potential loci of infection within the reproductive system, are therefore necessary in order to predict whether SARS-CoV-2 is likely to have any impact on fertility. Categorizations for protein expression correspond to the categorizations given by the Human Protein Atlas and the Human Proteome Map. Published scRNAseq datasets in human testicular (18) and non-human primate ovarian (19) tissue were used to assess the cell-type specific expression pattern of SARS-CoV-2 entry receptor ACE2 and entry-associated protease TMPRSS2 and their coexpression.	./cache/cord-277549-sg7tzhdm.txt	./txt/cord-277549-sg7tzhdm.txt