id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277529-z2r14w2k	Stella, Alessandro	Familial Mediterranean Fever and COVID-19: Friends or Foes?	2020-09-18		.txt	text/plain	3634	194	42	We were intrigued by the remarkable overlap between these clinical manifestations and some of the typical manifestations of Familial Mediterranean Fever (FMF), a largely recessively inherited monogenic inflammasomopathy (autoinflammatory disorder involving the inflammasome) caused by mutations in the MEFV gene that is particularly prevalent in the Mediterranean basin (14) . It is tempting to speculate that FMF patients carrying V726A and R761H variants-which represents the wild type residues in all bats and pangolin sequences-might modulate better their cytokine response to SARS-CoV-2 infection. Thus, the severity of COVID-19 disease in FMF patients, once infected, might be influenced, at least partially, depending on specific MEFV genotypes which shows country-specific differences. FMF, in which Pyrin activity and consequent ASC oligomerization are increased because of MEFV pathogenic variants, may therefore represent a unique opportunity as a disease model to investigate the regulation of the inflammatory response to novel emerging viruses.	./cache/cord-277529-z2r14w2k.txt	./txt/cord-277529-z2r14w2k.txt