id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277496-9ss09g6h	Thaweerat, Wajana	Current evidence on pancreatic involvement in SARS-CoV-2 infection	2020-05-27		.txt	text/plain	945	66	42	SARS-CoV-2, the infectious agent of COVID-19, attached to angiotensin-converting enzyme 2 (ACE2) at cell surface which act as a receptor for viral entry into host cells. 5 Chinese case series reported 9 patients with mild elevation of pancreatic enzymes less than triple of upper limit of normal which does not reach the cut-point for diagnosis and did not provide other supported evidence to fulfill the criteria of diagnosing acute pancreatitis such as characteristics of abdominal pain or imaging findings. 8 Acute pancreatitis in severe COVID-19 patients may result from direct attack of SARS-CoV-2 to pancreatic acinar cells or uncontrollable systemic inflammatory response from cytokine storm syndrome leading to multi-organ dysfunction including pancreatic injury. 14 Therefore, further autopsy of COVID-19 cases still required to provide histological evidence of SARS-CoV-2 infection in pancreatic cells. In conclusion, current evidence of pancreatic manifestation in COVID-19 patients are limited which further investigation is essential to unravel consequences of SARS-CoV-2 infection to both endocrine and exocrine function of pancreas.	./cache/cord-277496-9ss09g6h.txt	./txt/cord-277496-9ss09g6h.txt