id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277440-9nehpbg2	Grimm, Christian	Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?	2020-05-06		.txt	text/plain	1326	82	55	Genetic ablation of TPCs or TPC blockers have been previously shown to affect trafficking of both viruses and bacterial toxins through the endo-lysosomal system, reducing infectivity, including, e.g. cholera toxin, diphtheria toxin, Pasteurella multocida toxin, Anthrax toxin, Ebola virus, and MERS-CoV [5] [6] [7] . Indeed, it has been demonstrated before that SARS-CoV, like EBOV, displays late cell entry kinetics and that transport to NPC1+ (Niemann-Pick C1 protein) late endo-lysosomes is a rate-defining step [9] . The two-pore channels (TPC1, TPC2) are required by viruses such as EBOV (Ebola virus), MERS-CoV and SARS-CoV, orchestrating the interplay of virus and endolysosomal milieus such as trafficking from early to late endosomes, fusion of late endosomes with lysosomes, and facilitating releasing of viral RNA into the cytoplasm.	./cache/cord-277440-9nehpbg2.txt	./txt/cord-277440-9nehpbg2.txt