id author title date pages extension mime words sentences flesch summary cache txt cord-277239-cedoi5jr Bray, R. A. Development and validation of a multiplex bead based assay for the detection of antibodies directed against SARS-CoV-2 proteins 2020-09-03 .txt text/plain 4446 246 50 This study describes the development and validation of a high throughput multiplex bead based antibody detection assay with the capacity to identify, simultaneously, patient responses to five distinct SARS-CoV-2 proteins. This study describes the development and validation of a high throughput multiplex bead based antibody detection assay with the capacity to identify, simultaneously, patient responses to five distinct SARS-CoV-2 proteins. The data demonstrate that while most individuals have significant IgG responses to community coronaviruses, all pre-COVID-19 samples tested negative against the SARS-CoV-2 targets as well as to SARS and MERS S1 proteins. . https://doi.org/10.1101/2020.09.02.20185199 doi: medRxiv preprint multiplexed, solid phase assay compared to other platforms (e.g., ELISA) include the ability to assay multiple viral targets simultaneously (and thereby provide internal assay controls for coronavirus specificity), the capacity to incorporate additional SARS-CoV-2 proteins in the future, a relatively short assay time, high throughput and semiquantitative assessment of the antibody response. ./cache/cord-277239-cedoi5jr.txt ./txt/cord-277239-cedoi5jr.txt