id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276548-bh3w7oas	Ramkumar, K.	Elevated AXL expression following SARS-CoV-2 infection in non-small cell lung cancer	2020-09-30		.txt	text/plain	1114	81	51	title: Elevated AXL expression following SARS-CoV-2 infection in non-small cell lung cancer Our bulk data suggests that aerodigestive and lung cancer models express a broad range of ACE2 and TMRPSS2, particularly in epithelial cells, and would serve as good models for studying SARS-CoV-2 infection. Furthermore, SARS-CoV-2 infection reduces ACE2 expression and shifts cells to a more mesenchymal phenotype with loss of EPCAM and upregulation of ZEB1 and other EMT-associated genes. Methods: We analyzed mRNA expression of AXL and other TAM family members as well as angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, in treatment-naïve (n¼1016) and previously treated (n¼239) NSCLC tumors and in a panel of NSCLC cell lines (n¼70). Notably, expression of ACE2 was downregulated while that of AXL and ZEB1, an EMT transcription factor, were upregulated in NSCLC cells infected with SARS-CoV-2 as compared to mock infected cells, suggesting a shift to a more mesenchymal phenotype. D. Gibbons: Advisory/Consultancy, Research grant/Funding (self Advisory/Consultancy: Synta; Research grant/Funding (self): Bayer. L.A. Byers: Advisory/Consultancy, Research grant/Funding (self	./cache/cord-276548-bh3w7oas.txt	./txt/cord-276548-bh3w7oas.txt