id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276139-l13hbucu	Hashem, A. M.	Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients	2020-09-23		.txt	text/plain	4628	272	57	Our data show that SARS-CoV-2 specific IgG, IgM and neutralizing antibodies (nAbs) were readily detectable in almost all COVID-19 patients with various clinical presentations. Here, we studied the kinetics of SARS-CoV-2 specific antibodies to S1 and N viral proteins in blood samples collected between 4 to 70 days post-symptoms onset from a cohort of 87 COVID-19 patients with different disease presentations (i.e. mild, moderate or severe) or outcomes (i.e. survival vs death). Comparing the kinetics of antibody response in COVID-19 patients who had fatal outcomes to those who survived the infection also showed that early induction of anti-N IgG and IgM during the first 15 days post-disease onset is indicative of fatal outcomes (Figure 4c) . In this study we studied the characteristics and kinetics of SARS-CoV-2 specific antibody response (nAbs, IgG and IgM) in a series of serum samples collected from a total of 87 confirmed COVID-19 hospitalized patients over a period of 70 days post-symptoms onset.	./cache/cord-276139-l13hbucu.txt	./txt/cord-276139-l13hbucu.txt