id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276057-427ji6ze	Effenberger, Maria	Faecal calprotectin indicates intestinal inflammation in COVID-19	2020-04-20		.txt	text/plain	907	56	52	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-RNA was detected in the faeces in ~50% of patients with COVID-19 3 5 6 ; SARS-CoV-2 viral particles were observed by electron microscopy in stool samples from two patients without diarrhoea 2 ; and one study reported SARS-CoV-2 infection of the oesophagus, stomach, duodenum and rectum. 7 In this pilot study, we explored a relation between GI symptoms, intestinal inflammation (determined by FC) and faecal SARS-CoV-2-RNA in hospitalised patients with COVID-19 who did not require intensive care measures. We report evidence that SARS-CoV-2 infection in patients with COVID-19 indeed instigates an inflammatory response in the gut, as evidenced by diarrhoea, elevated FC (largely expressed by neutrophil granulocytes 7 ) and a systemic IL-6 response. Faecal SARS-CoV-2 RNA was not detected during acute diarrhoea but could be detected in asymptomatic patients with or without previous diarrhoeal symptoms.	./cache/cord-276057-427ji6ze.txt	./txt/cord-276057-427ji6ze.txt