id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275960-1m6poddy	Thieme, C. J.	The SARS-CoV-2 T-cell immunity is directed against the spike, membrane, and nucleocapsid protein and associated with COVID 19 severity	2020-05-16		.txt	text/plain	3244	217	52	Analyzing a cohort of COVID-19 patients with moderate, severe, and critical disease severity, we show that overlapping peptide pools (OPP) of all three proteins can activate SARS-CoV-2-reactive T-cells with a stronger response of CD4+ compared to CD8+ T-cells. Accordingly, very recent studies identified SARS-CoV-2 S-protein reactive T cell responses in patients suffering from moderate, severe, and critical COVID-19 4, 10 . Surprisingly, and in contrast to the endemic SARS-CoV infection, we detected the highest magnitude of CD4 + and CD8 + T cells reactive to S-, M-, and N-proteins in critical COVID-19 (Fig. 3) . Polyfunctional T cells showed higher frequencies in critical COVID-19 patients compared to moderate and severe cases (Fig. 3e ,f,n,o). In line with data showing an association between polyfunctionality and the stage of phenotypic differentiation 17 , we observed higher frequencies of CD8 + T cells with effector memory (TEM)/TEMRA phenotype in critical COVID-19 patients compared to moderate and severe cases (Fig S4) .	./cache/cord-275960-1m6poddy.txt	./txt/cord-275960-1m6poddy.txt