id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274945-6p5de7o2	Clevers, Hans	COVID-19: organoids go viral	2020-06-01		.txt	text/plain	1375	86	51	Indeed, enterocytes generated in ASC derived, small intestinal organoid cultures allowed cultivation of multiple human norovirus strains. There is no robust in vitro model beyond the use of ex vivo bronchus explant cultures for assessing the infectivity of emerging flu viruses in humans. Penninger and colleagues 7 demonstrated that SARS CoV2 could directly infect capillary organoids and kidney organoids, both established from human iPSCs. These observations may explain the spread of the virus through the body and the loss of kidney function in severely ill individuals. All three studies reported that the most common cell type of the intestinal epithelium, the enterocyte, is readily infected, suggesting that the intestine is a poten tial site of SARS CoV2 replication. Differentiated human airway organoids to assess infectivity of emerging influenza virus TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes Infection of bat and human intestinal organoids by SARS-CoV-2	./cache/cord-274945-6p5de7o2.txt	./txt/cord-274945-6p5de7o2.txt