id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274648-e0daf8w6	Madeddu, Paolo	Cardiovascular complications of COVID-19: evidence, misconceptions, and new opportunities	2020-06-08		.txt	text/plain	1940	95	41	The virus binds with its spike protein to the surface receptor angiotensin converting enzyme 2 (ACE2) to unlock human cells and begin infection. Likewise, it remains to be established whether repeated exposures or a single contact with massive doses of the virus, like in the case of clinical staff caring patients who are not known to be infected, can increase the risk of developing severe forms of the disease. The binding of SARS-CoV-2 to ACE2 is stronger than previous coronaviruses, due to difference in key amino acid residues allowing for enhanced interactions between the virus and human cells. Therefore, when considering severity of COVID-19, the low ACE2 levels observed in elderly people and those with cardiovascular disease seem to facilitate rather than protect from the disease (9) . The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts	./cache/cord-274648-e0daf8w6.txt	./txt/cord-274648-e0daf8w6.txt