id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274508-nigru1o8	Lally, Michelle	Metformin is associated with Decreased 30-day Mortality among Nursing Home Residents Infected with SARS-CoV2	2020-10-26		.txt	text/plain	937	64	41	title: Metformin is associated with Decreased 30-day Mortality among Nursing Home Residents Infected with SARS-CoV2 Design Retrospective cohort study Setting and Participants: 775 nursing home residents infected with SARS-CoV-2 who resided in one of the 134 Community Living Centers (CLC) of the Veterans Health Administration (VHA) during March 1, 2020 to May 13, 2020 were included. Results Relative to those not receiving diabetes medications, residents taking metformin were at significantly reduced hazard of death (adjusted HR 0.48, 95%CI 0.28, 0.84) over the subsequent 30 days from COVID-19 diagnosis. Conclusions and Implications Our data suggests a reduction in 30-day mortality following SARS-CoV-2 infection in residents who were on metformin-containing diabetes regimens. These findings suggest a relative survival benefit in nursing home residents on metformin, potentially through its mTOR inhibition effects. A recent focus on potential treatment for SARS-CoV-2 42 infection includes a pathway not usually considered for its "antiviral" property, the mammalian 43 target of rapamycin (mTOR) pathway.	./cache/cord-274508-nigru1o8.txt	./txt/cord-274508-nigru1o8.txt