id author title date pages extension mime words sentences flesch summary cache txt cord-274326-msbdrp3e Ren, Xiaohan Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19 2020-11-04 .txt text/plain 4897 291 46 title: Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19 We hypothesized that in critically ill patients, an inflammatory cytokine storm could directly attack specific cells in the kidney and testis due to their high expression of ACE2 and cytokine receptors, leading to injury of the urinary tract. Compared with the control group, patients with pulmonary arterial hypertension, chronic kidney disease, and diabetic Infection and Drug Resistance 2020:13 submit your manuscript | www.dovepress.com DovePress 3979 nephropathy, as well as smokers, exhibited higher expression levels of ACE2 in their affected tissues (kidneys or lungs) ( Figure 3A -D). 48 Considering the high level of IL6 in severe COVID-19 patients and the enrichment of the IL6 receptor in various testicular cells, this might be a reason for the potential orchitis caused by SARS-CoV-2 infection. ./cache/cord-274326-msbdrp3e.txt ./txt/cord-274326-msbdrp3e.txt