id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274279-f99nd3dx	Fantini, Jacques	Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection	2020-04-03		.txt	text/plain	4442	271	56	Using a combination of structural and molecular modelling approaches, this study showed that chloroquine (CLQ), one of the drugs currently under investigation for SARS-CoV-2 treatment, binds sialic acids and gangliosides with high affinity. A ganglioside-binding site in the Nterminal domain (NTD) of the spike (S) glycoprotein of SARS-CoV-2 was identified, and CLQ was shown to be a potential blocker of the S-ganglioside interaction which occurs in the first step of the viApril 10, 2020; 14:43 ] ral replication cycle (i.e. attachment to the surface of respiratory cells, mediated by the S protein). At this stage, attachment of the NTD to the ganglioside-rich microdomain involved the whole interface (i.e. Table 1 Energy of interaction of each amino acid residue of SARS-CoV-2 spike protein in contact with GM1 molecules. As CLQ and CLQ-OH are potential therapies for SARS-CoV-2 infection, it is important to check whether the amino acid residues identified as critical for ganglioside binding are conserved among clinical isolates.	./cache/cord-274279-f99nd3dx.txt	./txt/cord-274279-f99nd3dx.txt