id author title date pages extension mime words sentences flesch summary cache txt cord-273311-dl9u85nh Boscolo‐Rizzo, Paolo Challenges in interpreting the diagnostic performance of symptoms to predict COVID‐19 status: the case of anosmia 2020-06-25 .txt text/plain 430 34 54 Consequently, several studies have tried to estimate the sensitivity and specificity as well as the positive predictive value of self-reported new onset of smell and/or taste impairment for COVID-19 in populations of patients with flu-like symptoms. The first is that the standard diagnostic tool for diagnosis of SARS-CoV-2 infection, i.e. This article is protected by copyright. While the pooled sensitivity was 61% (95% CI, 55-68%), the pooled specificity reached 87% (95% CI, 80-92%); publication bias is possible (Figure 1b In conclusion, despite we believe that the new onset of smell and/or taste loss during COVID-19 pandemic should be considered a manifestation of SARS-CoV-2 infection until proven otherwise, sufficient to justify testing, self-isolation and the use of personal protective equipment by medical personnel interacting with these subjects, taken into account the above considerations, diagnostic performance of single symptoms should be fully understood and considered with caution when predicting SARS-CoV-2 infection in patients with flu-like symptoms. ./cache/cord-273311-dl9u85nh.txt ./txt/cord-273311-dl9u85nh.txt