id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273126-gceffbfp	Yuan, Kehu	Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein	2004-07-02		.txt	text/plain	3263	174	58	Subsequently, the highly conserved heptad repeat (HR) regions (HR1 and HR2) in the glycoprotein interact with each other to form a six-helix bundle structure, which facilitates the juxtaposition of the virus and cell membranes, leading to membrane fusion [9] . Based on the fusion mechanism described above, we used an approach that was successfully used for studying other enveloped viruses, such as HIV-1 and MHV, to identify the potent inhibitor for virus entry [16, 18, 19, 25] . Screened through the pseudotyped virus infection assay [7, [26] [27] [28] and validated with wild-typed virus infection, two peptides were identified, HR1-1 and HR2-18, which were able to inhibit the SARS-CoV entry process. Although we designed a series of peptides overlapping the HR2 region, only one peptide HR2-18 was identified to inhibit the entry of SARS-CoV with low inhibitor activity.	./cache/cord-273126-gceffbfp.txt	./txt/cord-273126-gceffbfp.txt