id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272423-o5yinjcz	Mao, Xiao-Yuan	iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2	2020-08-25		.txt	text/plain	1219	76	46	In a recent article, Yuen and colleagues present the first experimental evidence of SARS-CoV-2 infection in the human central nervous system using induced pluripotent stem cells (iPSCs)-derived platform including human neural progenitor cells, neurospheres, and three-dimensional brain organoids (Yuen, K.Y., and Huang, J.D. et al. Recently, Yuen and colleagues used induced pluripotent stem cells (iPSCs)-derived human neural progenitor cells (hNPCs), neurospheres, and three-dimensional (3D) brain organoids for evaluation of SARS-CoV-2 infection in the brain. provided the first experimental evidence showing that SARS-CoV-2 could replicate in hNPCs and neurospheres and also the novel virus could productively infect cortical neurons and NPCs in 3D brain organoids ( Figure 1 ). In summary, the data provided by Yuen and colleagues offer useful experimental evidence supporting that SARS-CoV-2 can infect the human brain using an iPSCs-derived platform including hNPCs, neurospheres, and 3D human organoids.	./cache/cord-272423-o5yinjcz.txt	./txt/cord-272423-o5yinjcz.txt