id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271544-i20105lq	Poston, Daniel	Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection	2020-10-11		.txt	text/plain	1366	87	53	Cross-reactive immune responses elicited by seasonal coronaviruses might impact SARS-CoV-2 susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in pre-pandemic sera from patients with prior PCR-confirmed seasonal coronavirus infection. One hypothesis is that cross reactive immune responses, elicited by prior 46 infection with seasonal coronaviruses impacts the course of SARS-CoV-2 infection, perhaps 47 providing a degree of protection against severe COVID-19 disease. The numbers of rVSV/SARS-2/GFP was assessed by flow cytometric detection of 92 GFP expression as described previously To assess whether prior infection by seasonal coronaviruses could elicit antibodies with 104 neutralization activity against SARS-CoV-2, we identified 37 serum samples collected prior to 105 the COVID19 pandemic from patients who were diagnosed using PCR with a seasonal 106 coronavirus 11-291 days (median 80 = days) prior to serum sample collection. . https://doi.org/10.1101/2020.10.08.20209650 doi: medRxiv preprint neutralize rVSV/SARS-CoV-2/GFP with NT50 values ranging from 96 to 5400.	./cache/cord-271544-i20105lq.txt	./txt/cord-271544-i20105lq.txt