id author title date pages extension mime words sentences flesch summary cache txt cord-271404-tu8u1b1d Gaunkar, Ridhima B COVID-19 in Smokeless Tobacco Habitués: Increased Susceptibility and Transmission 2020-06-25 .txt text/plain 3088 154 49 Smokeless tobacco (SLT) consumption is of particular concern in countries in South Asia with high population densities, as it facilitates exposure to SARS-CoV-2 within or between communities by the act of public spitting. SLT-induced higher expression of angiotensin-converting enzyme 2 receptors along with the presence of furin in the oral mucosa and dysfunctional immune responses among SLT habitués increase viral dissemination and an individual's susceptibility to COVID-19. There has not been much research on the increased risk of contracting COVID-19 for smokeless tobacco (SLT) users, although the use of these products is widely prevalent in South Asia and the Western Pacific region. The known action of the enzyme furin and the nicotine-induced increased expression of the ACE2 receptor result in COVID-19 viral tropism to the oral mucosal tissues in smokeless tobacco habitués [11] [12] [13] [14] [15] [16] [17] [18] [19] . ./cache/cord-271404-tu8u1b1d.txt ./txt/cord-271404-tu8u1b1d.txt