id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270994-1mmqfp7g	ul Qamar, Muhammad Tahir	Structural basis of SARS-CoV-2 3CL(pro) and anti-COVID-19 drug discovery from medicinal plants	2020-03-26		.txt	text/plain	2019	139	55	title: Structural basis of SARS-CoV-2 3CL(pro) and anti-COVID-19 drug discovery from medicinal plants Therefore, herein, we analysed the 3CL(pro) sequence, constructed its 3D homology model, and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal compounds. On January 21, the first article related to 2019-nCoV was 27 published, which revealed that 2019-nCoV belongs to the beta-coronavirus group, sharing 28 ancestry with bat coronavirus HKU9-1, similar to SARS-coronaviruses, and despite sequence 29 diversity its spike protein interacts strongly with the human ACE2 receptor [1] . Structure-based activity analyses and high-57 throughput studies have identified potential inhibitors for SARS-CoV and MERS-CoV 3CL pro 58 Our analyses identified nine novel non-toxic, 171 druggable natural compounds that are predicted to bind with the receptor binding site and 172 catalytic dyad (Cys-145 and His-41) of SARS-CoV-2 3CL pro ( Table 2 ; Fig. S5 ).	./cache/cord-270994-1mmqfp7g.txt	./txt/cord-270994-1mmqfp7g.txt