id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270886-m9na7cbm	Quadeer, Ahmed Abdul	Immunodominant epitopes based serological assay for detecting SARS-CoV-2 exposure: Promises and challenges	2020-08-15		.txt	text/plain	1216	60	37	Serological assays can also assist in detecting a large number of subclinical infections in the community arising largely due to the high proportion of asymptomatic COVID-19 cases, and in identifying donors with highly reactive antibodies for convalescent plasma therapy. In the current issue of EBioMedicine, Ng and colleagues attempt to address the above limitations of current serological assays by presenting a novel linear B cell immunodominant epitopes based assay for detecting exposure to SARS-CoV-2 [5] . Specifically, they identified a set of five immunodominant linear B cell epitopes from a peptide library of SARS-CoV-2 structural proteins by performing IgG reactivity test on pooled plasma samples of COVID-19 infected patients from Singapore. Consistent with multiple recent reports (e.g., [7, 8] ), the authors also found that the magnitude of IgG responses in COVID-19 patients against the identified epitopes correlated with disease severity. Second, the usefulness of serological assays in detecting prior exposure relies on the stimulation and persistence of SARS-CoV-2-specific antibody responses in infected patients.	./cache/cord-270886-m9na7cbm.txt	./txt/cord-270886-m9na7cbm.txt