id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270880-azslipmp	Cozzupoli, Grazia Maria	Possible Retinal Impairment Secondary to Ritonavir Use in SARS-CoV-2 Patients: A Narrative Systematic Review	2020-08-22		.txt	text/plain	2813	153	44	Seven single cases and one case series, reporting a total of 10 patients affected by retinal changes secondary to long-term ritonavir treatment, were included in the review. Although a recent randomized trial [3] involving hospitalized adult patients with confirmed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection has not shown significant benefits with lopinavir/ritonavir treatment beyond standard care, this protease inhibitor association is used in worldwide hospitals [4] . us, we conducted a narrative systematic review of the published reports describing the clinical features and imaging signs associated with ritonavirinduced retinal toxicity. Anyway, it is not illogical to hypothesize that the retinal toxic effects of both long-term hydroxychloroquine [32] and ritonavir therapies might appear also after short-term treatments, as in the case of SARS-CoV-2 patients, enhanced by the deterioration of renal and hepatic clearance function, respectively. e authors report a case of bull's eye maculopathy pattern in an HIV-positive patient, being treated with ritonavir for 13 years.	./cache/cord-270880-azslipmp.txt	./txt/cord-270880-azslipmp.txt