id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269537-h3lzl1un	Banerjee, Aditi	Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19	2020-05-23		.txt	text/plain	2937	189	39	Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca(++) caused by unfolded protein response (UPR) mediated by endoplasmic reticulum (ER) stress and is due to the exploitation of virus's own protein i.e., viroporins into the host cells. Considering the properties of both compounds in terms of anti-inflammatory, antioxidant, anti-pyrogenic, anti-viral and ER stress modulation and computational approaches revealing andrographolide docks with the SARS-CoV2 binding site, we predict that this combination therapy may have potential utility against COVID-19. Accumulating evidence suggests that ER stress and sustained UPR signaling are major contributors to the pathogenesis of several diseases, including inflammatory disorders and viral infections [15] and can increase the severity of these events [16] . Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment	./cache/cord-269537-h3lzl1un.txt	./txt/cord-269537-h3lzl1un.txt