id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269521-vq2m4c8q	Lucchese, Guglielmo	Molecular mimicry between SARS-CoV-2 and respiratory pacemaker neurons	2020-05-01		.txt	text/plain	815	59	43	Brainstem involvement has been proposed as a possible cause of respiratory failure in SARS-CoV-2 infection, given that the virus appears to have potential for inducing neurological damage, a number of neurological symptoms have been described, and SARS-CoV has been reported to massively infect the brainstem in both patients and experimental animals [3] . Indeed, the proteome of the virus (https://www.ncbi.nlm.nih.gov/nuccore/ MN908947) shares three sequences of six amino acids (GSQASS, LNEVAK, and SAAEAS) with three proteins, namely DAB1, AIFM, and SURF1 (as catalogued at www.uniprot.org) that are present in the human brainstem preBötC (Table 1 ) and are part of experimentally validated epitopes [10] . In the context of this peptide sharing between the preBötc, and SARS-CoV-2, it appears possible that immunological targeting of DAB1, AIFM1, and SURF1 might contribute to brainstem-related respiratory failure in COVID-19 patients and that a therapeutic benefit might come from immunomodulatory agents. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients	./cache/cord-269521-vq2m4c8q.txt	./txt/cord-269521-vq2m4c8q.txt