id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268169-xry3nhzt	Couturier, Aymeric	Indirect effects of severe acute respiratory syndrome coronavirus 2 on the kidney in coronavirus disease patients	2020-05-22		.txt	text/plain	3084	175	47	Among patients hospitalized for novel coronavirus disease (COVID-19), between 10 and 14% develop an acute kidney injury and around half display marked proteinuria and haematuria. Collapsing glomerulopathy is a peculiar form of focal segmental glomerulosclerosis (FSGS) [6] that has been well characterized in patients infected by human immunodeficiency virus (HIV) type 1 [7] . In order to better characterize the relationship between SARS-CoV-2 infection and collapsing FSGS, we performed an RT-PCR assay on the renal tissue specimen from Patient 1. Our results are in line with a recent inpress report that describes the presence of collapsing glomerulopathy and tubulointerstitial lesions in living COVID-19 patients of African origin, homozygous for APOL1 risk allele G1 and evidence of chronicity on kidney biopsy [12] . Although our findings do not definitely rule out a direct infection of kidney cells by SARS-CoV-2, COVID-19-related collapsing FSGS appears to be related to a viral-induced inflammatory response against a peculiar genetic background.	./cache/cord-268169-xry3nhzt.txt	./txt/cord-268169-xry3nhzt.txt