id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267723-loj718vd	Kloc, Małgorzata	Macrophages in diabetes mellitus (DM) and COVID-19: do they trigger DM?	2020-10-17		.txt	text/plain	2305	128	47	We also describe the DM-related changes in the monocyte/macrophages functions, how they could lead to the severe outcome of SARS-CoV-2 infection, and importantly, if and how they could initiate DM in DM-susceptible patients. Preclinical and clinical studies indicate that the increased numbers of innate immune cells, and produced by them inflammatory factors have causative and detrimental effects on the islets and β-cells in diabetes (Böni-Schnetzler and Meier 2019). As we wrote above, SARS-CoV-2 infects many types of cells expressing ACE2 receptors, including the macrophages and β-cell in the pancreas. One possibility is that, similar to the effect of SARS-CoV-2 in the lungs, the infection of pancreatic macrophages causes inflammatory cytokine and chemokines storm in the pancreas. Although, this scenario seemed the least likely because the direct damage to the pancreatic islets should result in higher than the reported incidence of COVID-19-induced diabetes, however, recent data presented in Nature News indicate that indead, the SARS-CoV-2 may cause direct damage to the insulin producing β-cells (Mallapaty 2020) .	./cache/cord-267723-loj718vd.txt	./txt/cord-267723-loj718vd.txt