id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267426-3eu9umx5	Yao, Hangping	Patient-derived mutations impact pathogenicity of SARS-CoV-2	2020-04-19		.txt	text/plain	4615	314	62	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; previously referred to as 32 2019-nCoV), associated with the ongoing outbreak of atypical pneumonia, has already 33 caused a global pandemic, despite China's extensive systematic effort to contain the 34 All rights reserved. 75 To address this, we characterized 11 SARS-CoV-2 viral isolates from patients (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. . https://doi.org/10.1101/2020.04.14.20060160 doi: medRxiv preprint 16 sequences and Taijima's D is -2.8874 with a nucleotide diversity (π) of 0.000641 (p < 229 0.05 according to simulations performed in (Tajima, 1989) , indicating that the 230 SARS-CoV-2 genome has an excess of low-frequency alleles due to recent population 231 expansions, consistent with the repeated bottlenecking events during viral infections.	./cache/cord-267426-3eu9umx5.txt	./txt/cord-267426-3eu9umx5.txt