id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266948-n7sltd1b	Ahamed, Jasimuddin	Severe aortic stenosis patient risk during the COVID-19 pandemic	2020-09-14		.txt	text/plain	1314	85	46	The patient risk assessment typically includes patient age and surgical risk; however, given the increased general risk of the procedure and that SARS-CoV-2 infection can be an additional and very dangerous comorbidity, suggesting the less invasive TAVR should be considered. 5 AS patients therefore may have increased risk for developing thromboembolic complications during the valve replacement procedure or during subsequent hospitalisation and recovery if they are infected with SARS-CoV-2. In fact, a recent study showed that a prosthetic aortic graft thrombosis patient died from COVID-19 and that anticoagulant and thrombectomy procedure were unsuccessful. 5 Therefore, direct thrombin inhibitors should be considered for AS patients who test positive for SARS-CoV-2, since both COVID-19 and AS procedure can increase the risk of thrombosis. Studies in animals have suggested that inhibitors of this system can upregulate ACE2 expression, which led some investigators to postulate that patients receiving those inhibitors may be at high risk of contracting a SARS-CoV-2 infection, which needs to be validated experimentally.	./cache/cord-266948-n7sltd1b.txt	./txt/cord-266948-n7sltd1b.txt