id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266888-ryvk6mte	Cai, Guoshuai	Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2	2020-06-15		.txt	text/plain	1444	83	53	In addition, we analyzed three microarray data sets of samples derived from healthy subjects and patients with chronic obstructive pulmonary disease (COPD), including small airway epithelium samples from current smokers (from GSE5058, n = 26 [7] ), bronchial airway epithelium samples from current and former smokers (GSE37147, n = 238 [9] ), and lung samples from white patients (n = 438) who underwent lung cancer surgery at the Institut Universitaire de Cardiologie et de Pneumologie de Québec (10). We identified upregulation of pulmonary ACE2 gene expression in ever-smokers compared with nonsmokers in all data sets, irrespective of tissue subset or COPD status (Figure 1) . The significant effect of smoking on ACE2 pulmonary expression identified in this study may suggest an increased risk for viral binding and entry of SARS-CoV and SARS-CoV-2 in lungs of smokers. We further evaluated the effect of smoking on ACE2 pulmonary expression in single bronchial epithelial cells from six never-smokers and six current smokers.	./cache/cord-266888-ryvk6mte.txt	./txt/cord-266888-ryvk6mte.txt