id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266710-3wdy16tw	Fintelman-Rodrigues, Natalia	Atazanavir, Alone or in Combination with Ritonavir, Inhibits SARS-CoV-2 Replication and Proinflammatory Cytokine Production	2020-09-21		.txt	text/plain	4822	298	55	Molecular dynamics analysis revealed that the root mean square deviation (RMSD) for the SARS-CoV-2 Mpro backbone presented different conformations in complex with ATV or LPV (see Fig. S3 ). As a control, the activity of SARS-CoV-2 Mpro in fractions from infected cells was evaluated by treatment with RTV, which inhibited activity in the molecular range of 31 to 38 kDa without a change in the 70-kDa region (Fig. 2 , RTV lanes). Since the results regarding the pharmacologic activity of ATV and ATV/RTV against SARS-CoV-2 replication in Vero cells were promising, we next investigated whether the proposed drug therapies could inhibit virus replication in a human epithelial pulmonary cell line (A549). We highlight ATV and ATV/RTV because our assay readout to quantify infectious virus particles reveals (i) a good profile of antiviral activity, (ii) higher potencies in respiratory cells, and (iii) the ability to reduce levels of proinflammation mediator in monocytes.	./cache/cord-266710-3wdy16tw.txt	./txt/cord-266710-3wdy16tw.txt