id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266512-xh6zed03	Scala, Enrico	Atopic statusprotects from severe complications of COVID‐19	2020-08-16		.txt	text/plain	1297	70	44	In infection, the Th2 response counteractsthe microbicidal Th1 response, which could limit the tissue damage induced by Th1-mediated inflammation (4) on one hand, but also cause a less efficient anti-virus response, as shown in a study on experimental Coronavirus 229E infection in healthy volunteers, where atopy appeared to be associated with a more severe rhinitis score (5) .Further, atopic subjects show a reduced expression of ACE2, the SARS-CoV-2 receptor, which could be associated with reduced susceptibility to the virus (6) . The multiple logistic regression analysis(details in supplementary material) confirmed a significant association between atopic status andmilder COVID-19;non-atopic patients had a significantly higher risk of having severe Covid-19 (OR adj 3.0, 95% CI 1.6-5.7, p =0.001) ( Table 1) In severe SARS-CoV-2 infection hyper-expressed cytokines include IFN-gamma, TNF-alpha, and IL-6, which cause fever, fatigue, flu-like symptoms, vascular leakage due to endothelial dysfunction, cardiomyopathy, hypotension, lung injury, activation of the coagulation cascade, and diffuse intravascular coagulation (7) .	./cache/cord-266512-xh6zed03.txt	./txt/cord-266512-xh6zed03.txt