id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266350-yybunc6z	Sinha, Saurabh K.	An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets	2020-05-13		.txt	text/plain	3180	165	48	From the binding energy and interaction studies, the Saikosaponins U and V showed the best affinity towards both the proteins suggesting them to be future research molecule as they mark the desire interaction with NSP15, which is responsible for replication of RNA and also with 2019-nCoV spike glycoprotein which manage the connection with ACE2. The docking simulation study of total 23 Saikosaponins (Supplementary file) was performed on the 1.9 A crystal structure of NSP15 Endoribonuclease from SARS CoV-2 in the complex with a citrate (PDB ID: 6W01) and prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up (PDB ID: 6VSB) which was retrieved from protein data bank (https://www.rcsb.org). Our observations revealed that, the Saikosaponin V having two oxane rings substituted with 3 hydroxyl group and the side chain contains 4 hydroxyl and an ester linkage showed very high binding with active site having a furrow between the two b-sheets, carries amino acids Lys290, Thr341, Tyr343 and Ser29.	./cache/cord-266350-yybunc6z.txt	./txt/cord-266350-yybunc6z.txt