id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266307-w56rii2p	Acheampong, Desmond Omane	Male Predisposition to Severe COVID-19: Review of Evidence and Potential Therapeutic Prospects	2020-09-09		.txt	text/plain	8837	467	46	The sex hormones, estrogens and androgens which exist in varying functional levels respectively in females and males are cited as the underlying cause for the differential immune response to COVID-19. In this review efforts are made to expand understanding and explain the possible roles of the immune system, the sex hormones and the angiotensin-converting enzyme (ACE) systems in male bias to severe COVID-19. Hence, females known for producing high-level estrogen will be better protected against infections including COVID-19 compared to their male counterparts. Hence, women are better protected against viral infections and for that matter the severe COVID-19 due to the over-expression of TLR7 in females compared to their male counterparts. This explains J o u r n a l P r e -p r o o f why prolong inflammation is very common in males infected with SARS-CoV-2 virus compared to females, and could be one of the factors that promote severe COVID-19 in men.	./cache/cord-266307-w56rii2p.txt	./txt/cord-266307-w56rii2p.txt