id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265813-2onv9mvl	Criado, Paulo Ricardo	Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms	2020-06-02		.txt	text/plain	5143	262	39	RESULTS: The pathophysiology of the disease is multifactorial: association with innate immune response, hypercoagulability state, lung tissue damage, neurological and/or gastrointestinal tract involvement, monocytic/macrophage activation syndrome, culminating in exaggerated cytokine secretion, called "cytokine storm", which leads to worsening and death. Until the present day, the cardinal points in severe COVID-19 are upregulated innate immune human response; hypercoagulable state; polymorphous clinical manifestations, due to pulmonary tissue damage, neurological and/ or gastrointestinal tract involvement; and fatal outcome in severe cases of macrophage activation syndrome-like (MAS) [102] . Excessive activation of inflammatory mediators creating a "cytokine storm", leading to damage to the endothelium; formation of multiple thromboses in the microvasculature of the skin; changes in the cellular component of immunity with activation of the complement system, as well as, the possibility of direct entry of SARS-CoV-2 entry via receptor ACE2 and protease TMPRSS2 in the human endothelial cell in dermal blood vessels cannot be excluded such as possible mechanisms if the possibility of virus circulation in the blood is proved.	./cache/cord-265813-2onv9mvl.txt	./txt/cord-265813-2onv9mvl.txt