id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264421-799n9wqj	Novelli, Antonio	Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients	2020-09-11		.txt	text/plain	3316	197	52	Several studies suggested that genetic variants in the ACE2 gene may influence the host susceptibility or resistance to SARS-CoV-2 infection according to the functional role of ACE2 in human pathophysiology. We therefore investigated the occurrence of ACE2 variants in a cohort of 131 Italian unrelated individuals clinically diagnosed with COVID-19 and in an Italian control population, to evaluate a possible allelic association with COVID-19, by direct DNA analysis. METHODS: As a pilot study, we analyzed, by whole-exome sequencing, genetic variants of ACE2 gene in 131 DNA samples of COVID-19 patients hospitalized at Tor Vergata University Hospital and at Bambino Gesù Children's Hospital, Rome. Indeed, several studies inferred that genetic variants in ACE2 gene may influence the individual susceptibility or resistance to SARS-CoV-2 according to the functional role of ACE2 in human pathophysiology [12] . In this study, we, therefore, investigated the occurrence of ACE2 variants in a cohort of 131 Italian SARS-CoV-2-positive patients, extracting data on ACE2 variants by direct DNA analysis.	./cache/cord-264421-799n9wqj.txt	./txt/cord-264421-799n9wqj.txt