id author title date pages extension mime words sentences flesch summary cache txt cord-263844-ixgejst2 Majdic, Gregor Could Sex/Gender Differences in ACE2 Expression in the Lungs Contribute to the Large Gender Disparity in the Morbidity and Mortality of Patients Infected With the SARS-CoV-2 Virus? 2020-06-09 .txt text/plain 1702 87 49 title: Could Sex/Gender Differences in ACE2 Expression in the Lungs Contribute to the Large Gender Disparity in the Morbidity and Mortality of Patients Infected With the SARS-CoV-2 Virus? If there is a sex difference in the expression of ACE2 in the lung, this could theoretically explain the gender disparity in COVID-19 disease. Epidemiological data show that a much larger number of men are severely affected by the disease, and there is an even more substantial gender difference in the mortality of patients with COVID-19. Here, I propose a novel hypothesis that not only addresses the significant gender differences in morbidity and mortality due to COVID-19 but also potentially tackles the low morbidity and especially the low mortality in children infected by the SARS-CoV-2 virus. Therefore, I propose the hypothesis that the expression of ACE2 protein is different between males and females and that this sex difference contributes to the gender disparity in morbidity and mortality from the COVID-19 disease. ./cache/cord-263844-ixgejst2.txt ./txt/cord-263844-ixgejst2.txt