id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-263803-0n41gylj	Villoutreix, Bruno O.	Prevention of COVID-19 by drug repurposing: rationale from drugs prescribed for mental disorders	2020-06-25		.txt	text/plain	1287	72	49	We also compared these 18 drugs with published molecules known to have in vitro antiviral activities [1, 2] using various chemoinformatics strategies (e.g., computation of molecular descriptors and compounds clustering carried out on J o u r n a l P r e -p r o o f about 300 molecules with in vitro antiviral activities on various viruses including SARS-CoV-2). Overall, our analysis suggests that the most commonly prescribed psychotropic drugs, including some antihistamine agents used as anxiolytics, possess in vitro antiviral activity ( Table 1 ). In summary, we propose that some of the drugs commonly prescribed to psychiatric patients could protect them from SARS-CoV-2 infection via the modulation of the endo-lysosomal pathway, membrane fusion and yet to be characterized interactions with specific receptors (e.g., nAChR, ACE2 and Sigma receptors, Fig. 1 ). Based upon the above analysis, we suggest that one of these CAD molecules or a combination could be used as preventive treatment against SARS-CoV-2 infection, especially drugs with reduced adverse effects (e.g., low dosage nicotine patch associated with an antihistamine agent).	./cache/cord-263803-0n41gylj.txt	./txt/cord-263803-0n41gylj.txt