id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-263002-f3itn0sb	Wagener, Frank A. D. T. G.	Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections	2020-06-19		.txt	text/plain	3943	248	39	Dimethyl fumarate (DMF) is a clinically used Nrf2 activator [86] that could possibly be used to prevent the many heme-induced complications during SARS-CoV-2 infection, such as edema, inflammation, and thrombosis and fibrosis by induction of the versatile HO-1 enzyme. Dimethyl fumarate (DMF) is a clinically used Nrf2 activator [86] that could possibly be used to prevent the many heme-induced complications during SARS-CoV-2 infection, such as edema, inflammation, and thrombosis and fibrosis by induction of the versatile HO-1 enzyme. These predisposing conditions, and inflammation in general, downregulate HO-1 expression and activity [67, 74, [100] [101] [102] [103] [104] [105] [106] , further supporting that this compromised protection and diminished tolerance against inflammatory and oxidative stress promotes adverse clinical outcome in COVID-19 patients. Since dexamethasone reduces hemolysis and induces HO-1 in macrophages [113] , it is tempting to speculate that this increased protection against free heme attenuates the severity of disease in COVID-19 patients.	./cache/cord-263002-f3itn0sb.txt	./txt/cord-263002-f3itn0sb.txt