id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262844-qeheeqe3	Xia, Xuhua	Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense	2020-04-14		.txt	text/plain	3305	204	53	The zinc finger antiviral protein (ZAP, known as ZC3HAV1 in mammals or hZAP in human), a key component in mammalian interferon-mediated immune response, binds specifically to CpG dinucleotides in viral RNA genomes via its RNA-binding domain (Meagher et al., 2019) . If a coronavirus infects a different host tissue with different ZAP abundance, then its RNA genome will experience different selection pressure against its CpG. The most striking pattern in Fig. 1 is an isolated but dramatic shift in the lineage leading to BatCoV RaTG13 which was reported (Zhou et al., 2020) (Theys et al., 2018) , but also in experimentally CpG dinucleotide-enriched viral genomes (Antzin-Anduetza et al., 2017; Burns et al., 2009; Fros et al., 2017; Trus et al., 2019; Tulloch et al., 2014; Wasson et al., 2017) . To search for a mammalian host with the potential to select viral lineages with low Poder, 2011; Pratelli, 2006) , have genomic ICpG and GC% values similar to those observed in SARS-CoV-2 and BatCoV RaTG13 (Fig. 3A) .	./cache/cord-262844-qeheeqe3.txt	./txt/cord-262844-qeheeqe3.txt