id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262282-9xh51cd1	Serwer, Philip	Optimizing Anti-Viral Vaccine Responses: Input from a Non-Specialist	2020-05-15		.txt	text/plain	4323	260	57	Without going into details concerning live vaccine production via eukaryotic viruses, I think it reasonable to assume that eukaryotic virus production is more difficult, more expensive and less rapid than the production of phages. However, current efforts to human-engineer improved antigens for anti-RNA virus vaccines have shown that neutralizing antibodies typically react with viral proteins that are in states that are context dependent and unstable [12, 13, 15, 20] . I take the liberty of responding here to the obvious objection that no membrane-covered, single-stranded RNA phage has ever been isolated [21] and that the pandemic viruses include influenza, Zika-type and coronaviruses, all in this category. A non-specialist observer reasonably concludes that DNA and RNA vaccines, when viewed in the context of our overall objective, are examples of type 2 strategy options. Given that eukaryotic viruses have doubling times much greater than those of phages (2-5 min for typical coliphages), meeting this objective implies that a live virus vaccine has to be already present in the environment.	./cache/cord-262282-9xh51cd1.txt	./txt/cord-262282-9xh51cd1.txt