id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262000-k32cb9ym	Li, Xue-Ting	Letter to the Editor: Increased plasma ACE2 concentration does not mean increased risk of SARS-CoV-2 infection and increased fatality rate of COVID-19	2020-09-07		.txt	text/plain	1911	94	44	title: Letter to the Editor: Increased plasma ACE2 concentration does not mean increased risk of SARS-CoV-2 infection and increased fatality rate of COVID-19 Angiotensin converting enzyme 2 (ACE2) has garnered widespread interest as the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus of COVID-19 pandemic, providing a critical link among COVID-19, inflammatory storm, ACE2 and cardiovascular disease 1,2 . Remarkably, recombinant human ACE2 (rhACE2), sACE2, ACE2-Fc, and ACE2-Ig are thought to be promising therapeutic approaches for COVID-19 patients with SARS-CoV-2 infection through competitive inhibiting the binding of viral Spike protein to mACE2 4 . Intriguingly, circulating Ang II level was obviously elevated in COVID-19 patients with lung injury (Table 1) 9 which further upregulates ADAM-17 activity by interacting with AT1 receptors, leading to more shedding of ACE2 and thereby accelerating renin-angiotensin-aldosterone system (RAAS)-mediated injury including severe cardiopulmonary damage (Fig. 1) (Table 1) 10 .	./cache/cord-262000-k32cb9ym.txt	./txt/cord-262000-k32cb9ym.txt