id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261959-pvufajw4	Karathanou, Konstantina	A graph-based approach identifies dynamic H-bond communication networks in spike protein S of SARS-CoV-2	2020-09-10		.txt	text/plain	9192	455	59	Markedly different H-bonding at these three clusters in open and pre-fusion conformations suggest dynamic H-bond clusters could facilitate structural plasticity and selection of a protein S protomer for binding to the host receptor, and proteolytic cleavage. The surface of the Severe Acute Respiratory Syndrome (SARS)-CoV-2 virion is decorated with large membrane-anchored spike proteins S (Figure 1 ) that bind to Angiotensin Converting Enzyme 2 (ACE2) receptor of the host cell (Briefing, 2020; Hoffmann et al., 2020; Li et al., 2003; Xiao et al., 2003; Zhou et al., 2020) . To derive clues about intra-molecular interactions with potential role in shaping structural dynamics of protein S, we computed two-dimensional graphs of all Hbonds of protein S in structures proposed for the closed, open, and pre-fusion conformation, and for ACE2 bound to an RBD fragment.	./cache/cord-261959-pvufajw4.txt	./txt/cord-261959-pvufajw4.txt