id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261566-fn08b0y2	Mudgal, Rajat	Prospects for mucosal vaccine: shutting the door on SARS-CoV-2	2020-09-15		.txt	text/plain	7060	413	38	15 The disease severity and lung damage in the case of SARS-CoV-2 infection can be directly correlated with the dysregulated immune response at 7-10 days after symptom onset and is characterized by exuberant production of cytokines including IL-2, IL-7, IL-10, MIP-1A, IP-10, and TNF-α. 53, [98] [99] [100] [101] [102] Ferrets are a suitable animal model for SARS-CoV vaccine evaluation as they support viral replication in the respiratory tract, develop similar disease symptoms, and display severe lung pathology. Potential ADE and waning of vaccine-induced immune response represent other obstacles in the development of a mucosal vaccine against SARS-CoV-2. Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice	./cache/cord-261566-fn08b0y2.txt	./txt/cord-261566-fn08b0y2.txt